Xorel Mups 20

✔️ Xorel MUPS 20 mg is generally well-tolerated. Reported side effects include:

Common: headache, nausea, vomiting, constipation, dry mouth, dizziness, sleepiness, muscle pain, appetite changes

Long-term therapy risks: Slightly increased risk of bone fractures (hip, wrist, spine), particularly in elderly patients or those with other risk factors for osteoporosis

✔️ Dosage & Administration of Xorel Mups 20

Adults:

1. Active duodenal ulcer: 20 mg once daily in the morning for 4 weeks; some may require an additional 4 weeks.
2. Active benign gastric ulcer: 20 mg once daily for 6 weeks; some patients may need an extra 6 weeks.
3. Erosive/ulcerative GERD: 20 mg once daily for 4–8 weeks; extended treatment may be considered if healing is incomplete.
4. GERD maintenance: 10–20 mg once daily, depending on patient response.
5. Zollinger-Ellison syndrome: Starting dose 60 mg once daily; may be titrated up to 120 mg/day, sometimes requiring divided doses.
6. H. pylori eradication: 20 mg twice daily with amoxicillin 1 g and clarithromycin 500 mg twice daily for 7 days.

Pediatric Use:

Limited data. Recommended doses for children 1–11 years:

<15 kg: 5 mg once daily (can increase to 10 mg if response is inadequate)

≥15 kg: 10 mg once daily for 12 weeks

1. Hepatic or renal impairment: No dose adjustment required.
2. Pediatric use: Safety and efficacy not established; use is not recommended.

Administration Instructions:

Tablets should be swallowed whole, preferably in the morning, with or without food.

Chewing or crushing the tablet is not recommended.

✔️ Drug Interactions

pH-dependent absorption drugs: Co-administration with ketoconazole or itraconazole may reduce antifungal efficacy; careful monitoring or dose adjustment may be necessary.

Atazanavir: Should not be taken concurrently due to reduced absorption.

Antacids: No significant interaction reported.

✔️ Contraindications

Hypersensitivity to Rabeprazole or any excipients

Pregnancy and breastfeeding (use only if benefits outweigh risks)

✔️ Pregnancy & Lactation

Pregnancy: FDA category C. Animal studies show no evidence of fertility impairment or fetal harm; no adequate human studies available.

Lactation: Rabeprazole is likely excreted in human milk; decisions regarding breastfeeding should weigh maternal benefit against potential infant risk.

✔️ Precautions & Warnings

Rule out malignancy before starting therapy, as symptomatic improvement does not exclude cancer.

Long-term use (>1 year) should be monitored.

Ensure adequate calcium and vitamin D intake in patients at risk of osteoporosis.

✔️ Storage:

Store below 30°C, away from light and moisture.

Keep out of reach of children.